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KMID : 0043319940170010039
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Archives of Pharmacal Research
1994 Volume.17 No. 1 p.39 ~ p.41
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A Facile Synthesis of N,N’-Disubstituted Ureas from Amide and Amine by Using N-Bromophthalimide (NBP) and Silvercetate in One Pot
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Park Min-Soo
Choi Chang-Uk
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Abstract
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Various N,N’-disubstituted ureas 5 were easily prepared from the corresponding primary amide 1 by tratment with N-Bromophthalimide $(NBP)-AgOAc-RNH 4 in dry N,N-dimrthylformamide (DMF). This reaction envolved the intemediate formation of isocyanate 3 from amide 1 via Hofmann rearrangement by treatment with AgOAc and NBP and nucleophilic addition of amine 4 to this isocyante 3. This method is simple enough to be applied to the synthesis of various N,N’-disubstututed ureas scale conviently.
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KEYWORD
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N-Bromophthalimide, lsocyanate, Silveracetae, N, N′-Disubstituted urea
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